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RRB NTPC Graduate Tier 1 2025 Shift-1 📅 09 Jun, 2025

A new mutation allows Plasmodium falciparum to exit the liver without maturing into merozoites. What would be the immediate consequence?

A
Absence of RBC rupture and reduced clinical symptoms
B
Direct infection of alveoli
C
Increased severity of disease
D
Immediate immune response and clearance
Result Summary
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RRB NTPC Graduate Tier 1
2025 • 09 Jun, 2025 • Shift-1
A new mutation allows Plasmodium falciparum to exit the liver without maturing into merozoites. What would be the immediate consequence?
Correct Answer
Absence of RBC rupture and reduced clinical symptoms
Pathological Mechanism Analysis: Malaria, caused by Plasmodium parasites, operates on a highly rigid lifecycle. Initially, the parasite multiplies within human ......
Ref/Book : RRB NTPC Graduate Tier 1 2025
Ref. Subject Biology
Chapter -
Ref. Topic Human Diseases
Pg. No -
💡 Analysis & Explanation
Pathological Mechanism Analysis ▼
Malaria, caused by Plasmodium parasites, operates on a highly rigid lifecycle. Initially, the parasite multiplies within human liver cells, maturing specifically into a form known as merozoites.
Interrupting the Lifecycle ▼
Only these mature merozoites possess the specialized biological machinery required to aggressively invade, replicate within, and eventually shatter Red Blood Cells (RBCs). It is this massive, synchronized destruction of RBCs that physically triggers the severe fevers, chills, and classical clinical symptoms of malaria.
Consequential Deduction ▼
If a mutation prevents the parasite from successfully transitioning into the merozoite stage, it completely loses its ability to attack the bloodstream. Without RBC invasion and subsequent rupture, the disease's acute symptomatic phase physically cannot commence.
Conclusion ▼
Thus, the immediate medical consequence is the absence of RBC rupture and heavily reduced clinical symptoms.
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